#5440 BONE TURNOVER MARKERS AND BONE MINERAL DENSITY 1 YEAR AFTER KIDNEY TRANSPLANTATION
نویسندگان
چکیده
Abstract Background and Aims Alterations of bone metabolism are a hallmark chronic kidney disease (CKD) patients do not completely ameliorate after transplantation. In the setting secondary analysis RCT, we evaluated changes turnover biomarkers (BTM) their associations with mineral density (BMD) as assessed by DXA. Method Sixty-six Kidney Transplant (KTx) recipients were enrolled between 2014-2017. these patients, at baseline (T0) 12 months (T12) measured BTM (Figure 1). The prevalence vitamin K deficiency was based on undercarboxylated-BGP (uc-BGP) cut-off: > = 4.5 ng/ml, whilst dephosphorylated-ucMGP (dp-ucMGP) considered cut-off >500 pmol/L levels. DXA data lumbar spine, femoral neck, total hip, one-third ultradistal radius both one year, evaluating in areal BMD (aBMD). Results expressed mean ±SD or median inter-quartile range, appropriate. Correlations investigated Spearman's analysis. age 51± 13 years, 34% female. BMI average 27.8 ± 5.5 kg/m2. 24 (39.3%) pre-emptive 37 (60.7%) dialysis 19% had history fracture. Figure 1 trend year KTx. We highlighted significant reduction PTH, CTX, P1NP, VKDPs. This latter while improving but restored. Table shows correlations percentage variation several sites evaluated. Conclusion first-year post-transplant, along improvement renal function, PTH values reduced well those CTX P1NP. Moreover, observed an inverse correlation BMD, translates into BMD.
منابع مشابه
Determinants of reduced bone mineral density and increased bone turnover after kidney transplantation: cross-sectional study.
AIM To analyze bone metabolism and the risk factors of bone loss in kidney transplant recipients. METHODS The bone mineral density (BMD) of the lumbar spine, femoral neck, and radius was determined by dual-energy X-ray absorptiometry in 52 patients 8 days to 228 months after kidney transplantation. Total and bone alkaline phosphatase (BAP), osteocalcin, procollagen, type I collagen telopeptid...
متن کاملIncreased bone turnover markers after renal transplantation.
Bone remodeling is a process that occurs continuously in a seemingly inactive tissue like bone. Because of decreased vitamin D synthesis, phosphorus retention and decreased calcium blood concentration, patients with chronic renal failure (CRF) develop secondary hyperparathyroidism. Elevated PTH levels shifts balance between osteoblast and osteoclast activity in favor of osteoclast activity and,...
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PURPOSE To determine the levels of bone and cartilage turnover markers in men with ankylosing spondylitis (AS) and to investigate their associations with disease activity, bone mineral density, and radiographic damage of the spine. PATIENTS AND METHODS This cross-sectional study enrolled 35 men with newly diagnosed AS. The bone mineral densities (BMD) of their lumbar spines and proximal femur...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2023
ISSN: ['1460-2385', '0931-0509']
DOI: https://doi.org/10.1093/ndt/gfad063c_5440